Prenylation differentially inhibits insulin-dependent immediate early gene mRNA expression
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چکیده
منابع مشابه
Kinetics of HCMV immediate early mRNA expression
Strong evidence supports the existence of direct and indirect connections between pre-mRNA synthesis and a number of pre-mRNA processing reactions, such as 5′cap formation, splicing and polyadenylation. The C-terminal domain (CTD) of RNA polymerase II (PolII), the enzyme complex that carries out pre-mRNA transcription, plays an important role in this (reviewed in Bentley, 1999; Hirose and Manle...
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Human cytomegalovirus (HCMV) starts its lytic replication cycle only in the G(0)/G(1) phase of the cell division cycle. S/G(2) cells can be infected but block the onset of immediate-early (IE) gene expression. This block can be overcome by inhibition of cyclin-dependent kinases (CDKs), suggesting that cyclin A2, the only cyclin with an S/G(2)-specific activity profile, may act as a negative reg...
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Neuronal stimulation leads to immediate early gene (IEG) expression through calcium-dependent mechanisms. In recent years, considerable attention has been devoted to the transcriptional responses after neuronal stimulation, but relatively little is known about the changes in chromatin dynamics that follow neuronal activation. Here, we use fluorescence recovery after photobleaching, biochemical ...
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The mammalian small intestinal epithelium is a continuously renewable population of cells which arise from a proliferative zone of undifferentiated stem cells within the crypts. Epidermal growth factor (EGF) is thought to play a role in the maintenance and proliferative response of the intestinal epithelium. In order to investigate the early changes in intestinal gene expression which occur in ...
متن کاملInfluence of Isoflurane on Immediate-Early Gene Expression
BACKGROUND Anterograde amnesia is a hallmark effect of volatile anesthetics. Isoflurane is known to affect both the translation and transcription of plasticity-associated genes required for normal memory formation in many brain regions. What is not known is whether isoflurane anesthesia prevents the initiation of transcription or whether it halts transcription already in progress. We tested the...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2016
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2016.04.067